Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice
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چکیده
منابع مشابه
Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.
A genetic variant in PNPLA3 (PNPLA3(I148M)), a triacylglycerol (TAG) hydrolase, is a major risk factor for nonalcoholic fatty liver disease (NAFLD); however, the mechanism underlying this association is not known. To develop an animal model of PNPLA3-induced fatty liver disease, we generated transgenic mice that overexpress similar amounts of wild-type PNPLA3 (PNPLA3(WT)) or mutant PNPLA3 (PNPL...
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OBJECTIVE Retinol-binding protein (RBP) 4 is an adipokine of which plasma levels are elevated in obesity and type 2 diabetes. The aims of the study were to identify determinants of plasma RBP4 and RBP4 mRNA expression in subcutaneous adipose tissue (SAT) and skeletal muscle and to investigate the association between RBP4 and in vivo measures of glucose metabolism. RESEARCH DESIGN AND METHODS ...
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Studies in mice suggest that adipocytes serve as glucose sensors and regulate systemic glucose metabolism through release of serum retinol-binding protein 4 (RBP4). This model has not been validated in humans. RBP4 was highly expressed in isolated mature human adipocytes and secreted by differentiating human adipocytes. In contrast to the animal data, RBP4 mRNA was downregulated in subcutaneous...
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The abbreviations used are: PPAR, peroxisome proliferator-activated receptor; PPRE, peroxisome proliferator response element(s); AOX, straight chain fatty acyl-CoA oxidase; L-PBE, peroxisomal enoylCoA hydratase/3-hydroxyacyl-CoA dehydrogenase bifunctional protein; PTL, peroxisomal 3-ketoacylCoA thiolase; G-6-P, glucose-6-phosphatase; C/EBPα, CCAAT enhancer-binding protein α; SREBP1, sterol regu...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2016
ISSN: 0270-9139
DOI: 10.1002/hep.28659